diff --git a/cli/command/container/completion.go b/cli/command/container/completion.go
index f988d2c0c1..23a1dedfd7 100644
--- a/cli/command/container/completion.go
+++ b/cli/command/container/completion.go
@@ -75,6 +75,11 @@ func addCompletions(cmd *cobra.Command, dockerCLI completion.APIClientProvider)
 	_ = cmd.RegisterFlagCompletionFunc("volumes-from", completion.ContainerNames(dockerCLI, true))
 }
 
+// completeDetachKeys implements shell completion for the `--detach-keys` option of `run` and `create`.
+func completeDetachKeys(_ *cobra.Command, _ []string, _ string) ([]string, cobra.ShellCompDirective) {
+	return []string{"ctrl-"}, cobra.ShellCompDirectiveNoSpace
+}
+
 // completeIpc implements shell completion for the `--ipc` option of `run` and `create`.
 // The completion is partly composite.
 func completeIpc(dockerCLI completion.APIClientProvider) func(cmd *cobra.Command, args []string, toComplete string) ([]string, cobra.ShellCompDirective) {
diff --git a/cli/command/container/run.go b/cli/command/container/run.go
index 78687ebe4c..f7f4ca0d1f 100644
--- a/cli/command/container/run.go
+++ b/cli/command/container/run.go
@@ -69,6 +69,7 @@ func NewRunCommand(dockerCli command.Cli) *cobra.Command {
 	command.AddTrustVerificationFlags(flags, &options.untrusted, dockerCli.ContentTrustEnabled())
 	copts = addFlags(flags)
 
+	_ = cmd.RegisterFlagCompletionFunc("detach-keys", completeDetachKeys)
 	addCompletions(cmd, dockerCli)
 
 	return cmd